Do chromatin remodeling complexes use ATP?
The major activities that are involved in nucleosome structure alterations use the energy supplied by ATP hydrolysis to affect nucleosomes. These enzymes are called ATP-dependent chromatin (or nucleosome) remodeling factors.
What are the three mechanisms by which chromatin remodelers can move nucleosomes?
nucleosome methylation nucleosome repositioning nucleosome sliding nucleosome acetylation nucleosome remodeling removal of nucleosomes.
What is the role of ATP-dependent chromatin-remodeling?
ATP-dependent chromatin remodeling is performed by enzymes—chromatin remodeling complexes. The united activity of these enzymes forms the dynamic properties of chromatin during different nuclear processes such as transcription, replication, DNA repair, homological recombination, and chromatin assembly.
How do chromatin-remodeling complexes work quizlet?
How do chromatin-remodeling complexes work? They use the energy from ATP hydrolysis to alter the arrangement of nucleosomes, rendering certain regions of the DNA more acceible to other proteins. The tails of the core histone proteins can be chemically modified by the covalent addition of what type of chemical group?
What is the mechanism of action of chromatin-remodeling complexes quizlet?
What is the mechanism of action of chromatin-remodeling complexes? They bind directly to the DNA and reposition nucleosomes to make the DNA more accessible. They remove methyl groups from the DNA itself, resulting in DNA that is more accessible. They add acetyl groups to histones to activate or repress transcription.
What enzyme opens chromatin?
Signaling Function of Remodeled Chromatin
Histone modification can open chromatin, thus permitting selective binding of transcription factors that, in turn, recruit RNA polymerase II (Turner, 2005). Varying levels and types of histone modifications have been shown to correlate with levels of chromatin activation.
Which of the following protein modifications can be used to regulate chromatin structure?
Histone modifications regulate the physical properties of chromatin, and its corresponding transcriptional state, either directly (eg acetyl groups that repel negatively charged DNA to create open chromatin conformation) or via protein adaptors termed effectors.
Are histones enzymes?
Histone modifying enzymes are involved in the post-translational modification of histone and non-histone substrates and are involved in the epigenetic control of important cellular functions. In particular, histone deacetylases (HDACs) are involved in control of gene expression, cell proliferation, angiogenesis, etc.