Why is telomerase necessary during the replication of eukaryotic chromosomes?
Why is telomerase necessary during the replication of eukaryotic chromosomes? during DNA replicati, ends of molecules lack ends… primase doesn’t reach. telomerase adds ends, so they won’t deteriorate.
Why is it necessary for telomerase to extend the end of chromosomes?
Telomerase, an enzyme with a built-in RNA template, extends the ends by copying the RNA template and extending one end of the chromosome. … In this way, the ends of the chromosomes are protected. This is important as evidence indicates telomere length may play a role in regulating cell division and the process of aging.
What is telomerase and why is it important?
The enzyme telomerase adds TTAGGG repeats onto mammalian telomeres, which prevents their shortening. … The activation of telomerase in malignant cancers seems to be an important step in tumorigenesis, whereby the cell gains the ability of indefinite proliferation to become immortal.
What is the function of telomerase?
Telomerase is the enzyme responsible for maintenance of the length of telomeres by addition of guanine-rich repetitive sequences. Telomerase activity is exhibited in gametes and stem and tumor cells.
What are telomeres and why are they important how does telomerase play a role quizlet?
Telomerase allows for telomere length and equilibrium maintenance by adding on repeats to the end of the chromosome. … RNA component – contains a sequence that is complementary to the telomere sequence that is added. This template region can be used to add to the ends of the chromosomes.
What is the importance of telomeres and telomerase in the maintenance of the structure of chromosome?
Telomeres serve as substrates for telomerase, the enzyme responsible for adding DNA to the ends of chromosomes, thus maintaining chromosome length [9, 16]. To compensate for the DNA erosion inherent in genetic stability, telomerase adds tandem array of simple-sequence repeats at the chromosome ends.
What is the significance of the telomere and telomerase in DNA replication?
Telomeres are the physical ends of eukaryotic chromosomes. They protect chromosome ends from DNA degradation, recombination, and DNA end fusions, and they are important for nuclear architecture. Telomeres provide a mechanism for their replication by semiconservative DNA replication and length maintenance by telomerase.
Why is the enzyme telomerase important in some cells quizlet?
Why are telomeres important? They stabilize the ends of chromosomes.
Why is telomerase not active in somatic cells?
Telomerase activity is absent in most normal human somatic cells because of the lack of expression of TERT; TERC is usually present. On the other hand most mouse cells have telomerase activity (Blasco, 2005). … The absence of telomerase activity in most human somatic cells results in telomere shortening during aging.