What would the genotype of the offspring have to be in order for them to have cystic fibrosis?

What genotype must a person have to have cystic fibrosis?

Cystic fibrosis (CF) is a genetic disease. This means that it is inherited. A child will be born with CF only if they inherit one CF gene from each parent. A person who has only one CF gene is called a CF carrier.

The Genetics of Cystic Fibrosis.

Ethnic Background Risk of CF Mutation Risk of Child with CF
Asian-American 1 in 90 1 in 100,000

What genotypes would the parents have to be to have a child with cystic fibrosis?

A person must inherit 2 CF genes to have CF disease. When your child was conceived, he or she received a CF gene from both you and your partner. A child can inherit CF only if both parents carry a CF gene (that is, each parent either has CF or is a carrier) and both parents pass the CF gene on to their child.

What is the genotype of someone without cystic fibrosis?

Someone who is heterozygous (Ff) or homozygous (FF) for the dominant allele will not develop cystic fibrosis.

What is the genotype of a person with CF?

The genotype of the carrier is Ff (one dominant non-disease gene, F, and one recessive, CF gene, f).

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What chromosome is cystic fibrosis on?

The seventh pair of chromosomes has a gene called the CFTR (cystic fibrosis transmembrane conductance regulator) gene. Changes (mutations) or errors in this gene are what cause CF.

What are the other 22 chromosomes called?


Humans have 23 pairs of chromosomes–22 pairs of numbered chromosomes, called autosomes, and one pair of sex chromosomes, X and Y.

What are the heterozygous genotypes?

(HEH-teh-roh-ZY-gus JEE-noh-tipe) The presence of two different alleles at a particular gene locus. A heterozygous genotype may include one normal allele and one mutated allele or two different mutated alleles (compound heterozygote).

What is the Punnett square for cystic fibrosis?

To predict how many offspring will have a particular genotype you use a Punnett square. For example in cystic fibrosis if both parents are heterozygous, each child has a 25% chance of being born with cystic fibrosis.

Mendelian Genetics.

Genotype Phenotype
f f Homozygous recessive Cystic fibrosis (has symptoms)

How does CFTR cause cystic fibrosis?

The cystic fibrosis transmembrane conductance regulator (CFTR) gene contains the instructions for making the CFTR protein. In people with CF, mutations in the CFTR gene cause the CFTR protein to malfunction, leading to a buildup of thick mucus.