Which mutation is the most likely to result in no effect to the phenotype of a cell?
As a consequence of the degeneracy of the genetic code, a point mutation will commonly result in the same amino acid being incorporated into the resulting polypeptide despite the sequence change. This change would have no effect on the protein’s structure, and is thus called a silent mutation.
Do most mutations have no effect on phenotype?
A mutation is a random change in DNA which therefore affects a gene and/or chromosome . Most mutations have no effect on the phenotype.
Why do most mutations have no effect on the phenotype?
After mutagen treatment, the vast majority of base pair changes (especially substitutions) have no effect on the phenotype. Often, this is because the change occurs in the DNA sequence of a non-coding region of the DNA, such as in inter-genic regions (between genes) or within an intron region.
What type of mutations affect the phenotype?
Recessive mutations lead to a loss of function, which is masked if a normal copy of the gene is present. For the mutant phenotype to occur, both alleles must carry the mutation. Dominant mutations lead to a mutant phenotype in the presence of a normal copy of the gene.
Which type of mutation has no effect on the organism?
The majority of mutations have neither negative nor positive effects on the organism in which they occur. These mutations are called neutral mutations. Examples include silent point mutations. They are neutral because they do not change the amino acids in the proteins they encode.
What type of mutation has no effect on the protein?
Silent mutations occur when the change of a single DNA nucleotide within a protein-coding portion of a gene does not affect the sequence of amino acids that make up the gene’s protein.
Which kind of mutation has no effect on gene function?
Silent mutation: Some mutations that change DNA bases do not have any effect on the sequence of amino acids in the protein. These mutations are called silent mutations and they do not affect the structure or function of the protein because there is no effect on the amino acid sequence.
Does frameshift mutation affect phenotype?
Thus, frameshift mutations typically exhibit complete loss of normal protein structure and function. Changes from mutant to wild-type phenotype may be due to changes within the mutant allele itself or to changes in some other gene that will result in a suppressor allele.
How can a silent mutation affect phenotype?
“Silent” mutation: does not change an amino acid, but in some cases can still have a phenotypic effect, e.g., by speeding up or slowing down protein synthesis, or by affecting splicing.