What is a chromatin state?
In the more general sense, the “chromatin state” of a genomic region can refer to the set of chromatin-associated proteins and histone modifications in that region. These are most often assayed by ChIP-seq, but also ATAC-seq, DNase-seq, ChIP-exo, and other methods.
Is chromatin found in prokaryotic cells?
Eukaryotic chromosomes are composed of chromatin, and each consists of two complementary strands of DNA coiled tightly around histones. The structure of chromatin is scaffolded, with three distinct levels.
|Eukaryotic Chromosome||Prokaryotic Chromosome|
|Location||Nucleus||Nucleoid (region in cytoplasm)|
Where and how are chromosomes formed?
Answer: In the nucleus of each cell, the DNA molecule is packaged into thread-like structures called chromosomes. Each chromosome is made up of DNA tightly coiled many times around proteins called histones that support its structure.
Where did the nucleolus come from?
Nucleoli were first isolated in the 1950s, from starfish oocytes. Then, in the early 1960s, a boomlet of studies led to one of the epochal discoveries in the modern era of genetics and cell biology: that the nucleolus is the site of ribosomal RNA synthesis and nascent ribosome assembly.
Where are histones present?
Histones are a family of basic proteins that associate with DNA in the nucleus and help condense it into chromatin, they are alkaline (basic pH) proteins, and their positive charges allow them to associate with DNA. They are found inside the nucleus of eukaryotic cells.
How are ribosomes made?
Ribosome biogenesis is the process of making ribosomes. In prokaryotes, this process takes place in the cytoplasm with the transcription of many ribosome gene operons. In eukaryotes, it takes place both in the cytoplasm and in the nucleolus.