Quick Answer: What is associated with telomere length?

What contributes to telomere length?

Telomere length is affected by a combination of factors including donor age [16], genetic, epigenetic make-up and environment [17–20], social and economic status [21,22], exercise [21], body weight [12,23], and smoking [12,24]. Gender does not seem to have any significant effect on the rate of telomere loss [13].

What is short telomere length associated with?

Short Telomere Length is Associated with Aging, Central Obesity, Poor Sleep and Hypertension in Lebanese Individuals.

How is telomere length determined?

Telomere length was quantified by comparing the amount of the telomere amplification product (T) to that of a single-copy gene (S), with amplification of the telomere and single gene proceeding in separate wells or tubes.

Is telomere length a biomarker?

Telomeres, the DNA-protein structures located at the ends of chromosomes, have been proposed to act as a biomarker of aging. … Although telomere length is implicated in cellular aging, the evidence suggesting telomere length is a biomarker of aging in humans is equivocal.

What are shortened telomeres?

When telomeres become abnormally short, cells can no longer divide effectively. An inherited mutation (change in the DNA code) in the gene that produces the telomere-lengthening enzyme called telomerase disables the enzyme and causes telomeres to shorten at a faster rate.

What is a telomere and what does it do?

A telomere is a repeating DNA sequence (for example, TTAGGG) at the end of the body’s chromosomes. The telomere can reach a length of 15,000 base pairs. Telomeres function by preventing chromosomes from losing base pair sequences at their ends. They also stop chromosomes from fusing to each other.

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What determines life length?

The duration of human life (longevity) is influenced by genetics, the environment, and lifestyle. The siblings and children (collectively called first-degree relatives) of long-lived individuals are more likely to remain healthy longer and to live to an older age than their peers. …