# Question: What formula do you use to calculate allele frequency?

Contents

## How do you calculate allele and genotype frequencies?

The frequency of genotype AA is determined by squaring the allele frequency A. The frequency of genotype Aa is determined by multiplying 2 times the frequency of A times the frequency of a. The frequency of aa is determined by squaring a.

Genotype Expected Frequency
aa or A2A2 q * q = q2

## How do you find frequency?

To calculate frequency, divide the number of times the event occurs by the length of time. Example: Anna divides the number of website clicks (236) by the length of time (one hour, or 60 minutes). She finds that she receives 3.9 clicks per minute.

## How do you find the minor allele frequency?

Find MAF/MinorAlleleCount link. MAF/MinorAlleleCount: C=0.1506/754 (1000 Genomes); where C is the minor allele for that particular locus; 0.1506 is the frequency of the C allele (MAF), i.e. 15% within the 1000 Genomes database; and 754 is the number of times this SNP has been observed in the population of the study.

## How do you calculate carrier frequency?

The carrier frequency can then be calculated as 2X99/100×1/100 which approximates to 1 in 50. Thus a rough approximation of the carrier frequency can be obtained by doubling the square root of the disease incidence. For an X-linked disorder the frequency of affected males equals the frequency of the mutant allele, q.

IT IS INTERESTING:  Can someone with Down syndrome have a normal child?

## How do you find the equilibrium frequency of alleles?

We solve this for q to give the equilibrium allele frequency , q-hat: q = sqrt(u/s) (sqrt stands for square root). Most mutation rates are fairly small numbers (about 106), so this equation suggests that deleterious alleles will be maintained in mutation selection balance at fairly low frequencies.