Is insulin a mitotic poison?

What are mitotic poisons?

Any chemical compound that kills dividing cells. Some mitotic poisons are spindle poisons (q.v.), and others block topoisomerases (q.v.). Poisoned cells are arrested at the spindle or DNA damage checkpoints, and they subsequently undergo apoptosis (q.v.). From: mitotic poison in A Dictionary of Genetics »

Which of the following drug is mitotic spindle poison?

Spindle poisons, such as paclitaxel and vinblastine, exert their potent anti-neoplastic effects through activation of the spindle assembly checkpoint (SAC), thereby arresting cells in mitosis. Unfortunately, only certain cancers are susceptible to these drugs, and many patients fail to respond to treatment.

Is cyanide a mitotic poison?

All these are mitotic poisons which inhibit the cell division. … During mitosis Cyanide inhibit ATP synthesis and Protein translation process and thus inhibit the prophase stage of mitosis. Ribonuclease block the prophase stage of mitosis .

Why is colchicine called mitotic poison?

(a)Colchicine is an alkaloid obtained from the corms of Autumn crocus. The alkaloid inhibits the formation of spindle by preventing assembly of microtubules. … As a result, the colchicine treated meristematic cells show doubling of chromosome.

What is the meaning of mitotic?

: of, relating to, involving, or occurring by cellular mitosis mitotic cell division mitotic recombination Microtubules move material through the cell and, in particular, form an important component of the mitotic spindle, which is a structure that separates the duplicated sets of chromosomes in the course of cell …

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Which of the following drugs would be considered a mitotic inhibitor?

List of Mitotic inhibitors:

Drug Name Avg. Rating Reviews
Taxotere (Pro) Generic name: docetaxel 5.0 9 reviews
Halaven (Pro) Generic name: eribulin 9.4 9 reviews
Taxol (Pro) Generic name: paclitaxel 8.4 7 reviews
Abraxane Generic name: paclitaxel protein-bound 6.2 6 reviews

What are anti mitotic drugs?

Listen to pronunciation. (AN-tee-my-TAH-tik AY-jent) A type of drug that blocks cell growth by stopping mitosis (cell division). They are used to treat cancer.

Which of the following is a well known mitotic poison?

The vinca alkaloids, mitotic spindle poisons derived from the periwinkle plant, include vincristine, vinblastine, vinorelbine, and vindesine.

Is cisplatin a mitotic inhibitor?

Chemotherapeutic agents include alkylating agents (cyclophosphamides), anthracycline antibiotics (doxorubicin), platinum compounds (cisplatin), mitotic inhibitors (vincristine), antimetabolites (5-fluorouracil), camptothecin derivatives (topotecan), biological response modifiers (interferon), and hormonal therapies ( …

What is colchicine mitosis?

The effect of colchicine, which inhibits microtubule polymerization and thus assembly of the mitotic spindle, demonstrates the presence of another checkpoint in the cell cycle. When colchicine is added to cultured cells, the cells enter mitosis and arrest with condensed chromosomes.

What are antimetabolite drugs?

Antimetabolites are a form of chemotherapy drug. They’re one of the most commonly used therapies to treat cancer. And they’re one of the oldest, dating back to the 1940s, when doctors used a medication that’s now considered an antimetabolite to treat children with leukemia.