How do you calculate p-value in Hardy Weinberg?
To calculate the allelic frequencies we simply divide the number of S or F alleles by the total number of alleles: 94/128 = 0.734 = p = frequency of the S allele, and 34/128 = 0.266 = q = frequency of the F allele.
What is P in the Hardy-Weinberg equilibrium?
Hardy-Weinberg Equations and Analysis. According to the Hardy-Weinberg principle, the variable p often represents the frequency of a particular allele, usually a dominant one. For example, assume that p represents the frequency of the dominant allele, Y, for yellow pea pods.
How do you calculate p and q allele frequencies?
To determine q, which is the frequency of the recessive allele in the population, simply take the square root of q2 which works out to be 0.632 (i.e. 0.632 x 0.632 = 0.4). So, q = 0.63. Since p + q = 1, then p must be 1 – 0.63 = 0.37.
How do you compute the p-value?
The p-value is calculated using the sampling distribution of the test statistic under the null hypothesis, the sample data, and the type of test being done (lower-tailed test, upper-tailed test, or two-sided test). The p-value for: a lower-tailed test is specified by: p-value = P(TS ts | H is true) = cdf(ts)
How do you calculate P and Q?
We can calculate the values of p and q, in a representative sample of individuals from a population, by simply counting the alleles and dividing by the total number of alleles examined. For a given allele, homozygotes will count for twice as much as heterozygotes.
What do PQ p2 2pq and q2 represent?
p2 +2pq + q2 = 1 Where p2 represents the frequency of the homozygous dominant genotype, q2 represents the frequency of the recessive genotype and 2pq is the frequency of the heterozygous genotype.